Given the presence of sub-patent asymptomatic malaria burden that cannot be detected by microscopy [207], and P. falciparum parasites with histidine-rich protein 2 (pfhrp2)and histidine-rich protein 3 (pfhrp3) gene deletions that can escape the current HRP2 based-RDTs detection [208], the estimated burden of malaria- helminth co-infection might be underestimated in these 24 articles. This evidence concerns the gene HTN3 and coinfection.