An intervention using VR and humidified phytoncides, α- and β-pinene, and limonene, in a simulated forest exposure intervention as a substitute for forest bathing in AXSpA patients with chronic or breakthrough pain and cancer patients with early-stage solid tumors (HR + HER2- breast cancer and prostate cancer) who have completed surgery or chemo- and/or radiation therapy (exclusive of hormone therapy) is possible in a lab setting. This evidence concerns the gene ERBB2 and breast carcinoma.