Many clinical studies and some meta-analyses have confirmed that there are some individuals apparently free of cardiac disease with hs-cTnI or hs-cTnT concentrations in the third tertile of the distribution values of biomarkers (i.e., still below the 99th percentile URL), who are at higher risk of earlier cardiac or non-cardiac mortality and/or rapid progression to HF [84,85]. This evidence concerns the gene TNNI3 and hydrops fetalis.