To improve risk stratification and prognostic accuracy in patients undergoing non-cardiac surgery, BNP and NT-proBNP have gained clinical consensus, especially for the detection of subclinical heart failure (HF) [46,47], and cTnI and cTnT for the identification of myocardial damage [43,44,45,46,47,48,49,50,51]. This evidence concerns the gene TNNI3 and hydrops fetalis.