siRNAs targeting genes whose expression is enhanced in tumors, such as marker B-cell lymphoma-2 (BCL2) and baculoviral IAP repeat-containing 5 (BIRC5) as well as genes with regulatory roles in sustaining cancer cell proliferation and migration, were used for NP functionalization and were found to selectively blockade the cancer cell proliferation of oral [115] and glioblastoma [78] cancer cell models. Here, BIRC5 is linked to cancer.