INS and diabetes mellitus: Diabetes mellitus (DM) refers to a group of chronic diseases characterized by high blood glucose that can be called hyperglycemia [1].There are two well-known types of diabetes: T1DM represents 5% to 10% of all diabetic cases and it is caused by a deficiency of insulin production.T2DM that has a direct correlation with insulin resistance and relative insulin deficiency, is also considered as the most common type in diabetes which represents 90% to 95% of worldwide cases [2].