By using APP/PS1/tau triple transgenic (3 × Tg) mice as a model of AD, Yang et al. [168] revealed that cornel iridoid glycoside, the dominant active constituent of C. officinalis, could ameliorate learning and memory impairments of 3 × Tg mice by down-regulating the expression of Aβ and full-length amyloid precursor protein, as well as decreasing the hyper-phosphorylation of tau protein. This evidence concerns the gene APP and Alzheimer disease.