On the other hand, the biological effect of phenolic compounds on obesity, these compounds maintain other functions, such as the regulation of insult oxidative, inflammation, and autophagy in diabetic nephropathy due to the action mechanism of ferulic acid, which is based on the regulation of the AGE, MAPK, and NF-kB pathways. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.