Among the compounds reported with beneficial effects are flavonoids, polyphenols, betalains, and fiber, which have been studied as factors with probable effects on specific pathways (PPARα, cyclooxygenase-2, glucose transporter (GLUT4), SIRT1, and PGC1-α) conferring anti-inflammatory activities, with remarkable implications for health and disease [15,16,17] Therefore, this review aims to provide a comprehensive overview of recent studies about the possible role and effect of specific bioactive compounds on weight management and obesity consequences. This evidence concerns the gene SLC2A4 and obesity due to melanocortin 4 receptor deficiency.