In overweight women and those with obesity, the consumption of epigallocatechin-gallate and resveratrol (282 mg/d and 80 mg/d, respectively) for 12 weeks did not cause changes in adipocyte size and distribution, but caused changes in pathways related to adipogenesis (β-estradiol and Prolactin), the cell cycle and apoptosis were downregulated, as well as oxidative stress (nuclear factor and erythroid 2-like 2 (NRF2)) and inflammation (TNF-α) [178]. The gene discussed is NFE2L2; the disease is obesity due to melanocortin 4 receptor deficiency.