Among the compounds reported with beneficial effects are flavonoids, polyphenols, betalains, and fiber, which have been studied as factors with probable effects on specific pathways (PPARα, cyclooxygenase-2, glucose transporter (GLUT4), SIRT1, and PGC1-α) conferring anti-inflammatory activities, with remarkable implications for health and disease [15,16,17] Therefore, this review aims to provide a comprehensive overview of recent studies about the possible role and effect of specific bioactive compounds on weight management and obesity consequences. This evidence concerns the gene SLC2A4 and Obesity.