MAPK8 and obesity due to melanocortin 4 receptor deficiency: It has been observed that obesity is related to metabolic pathways, food intake, and energy expenditure (Figure 2), which leads to the alteration of various inflammatory pathways, such as Janus-N-terminal kinase system/signal transducer and transcription activators (JNK/STAT), IκB-kinase β, and protein kinase C (PKC) [44,45], Besides an increased infiltration of cells into adipose tissue [46,47,48,49], due to the systemic circulation of inflammatory factors that stimulate the endothelial cells.