WNK2 and Hepatic fibrosis: We have previously shown that: (i) α-CGRP stimulates cAMP-dependent biliary proliferation, senescence, and liver fibrosis by enhanced biliary secretion of SASPs [17,23]; (ii) knock-out of α-CGRP reduces biliary hyperplasia by decreased cAMP levels [17], which is a second messenger regulating biliary proliferation [24]; and (iii) knock-out of α-CGRP decreases biliary senescence and liver fibrosis through the decreased activation of the p38 and C-Jun N-terminal protein kinase mitogen-activated protein kinase (MAPK) signaling pathway [23].