Table 8 examines the cognitive and motor outcomes in animal experiments of HD models after GA immunization. Studies examined BDNF expression and its effect on reducing pathogenic astroglial cells. In these models, GA restored BDNF levels and decreased neurodegeneration [139,140,142]. With GA use, lifespan was prolonged and disease progression was delayed [139,140]. The gene discussed is BDNF; the disease is Huntington disease.