IARS1 and arthritic joint disease: Finally, our enrichment analyses also disclosed that the cytokine/growth factor profile of ACEs is associated with many immune and autoimmune disorders, such as arthritis, inflammatory bowed disease, demyelinating and neuroinflammatory disease, and atherosclerosis, which show a strong comorbidity with MDD/MDE, which was previously ascribed to the activated IRS and OSTOX pathways [82].