CLCNKB and Bloom syndrome: While GS is an autosomal-recessive disease produced by mutations in a single gene (SLC12A3) [57], BS can be caused by mutations in six distinct genes (SLC12A1, KCNJ1, CLCNKA, CLCNKB, BSND, and MAGED2) and be transmitted in three inheritance patterns (X-linked, autosomal-recessive, or autosomal-dominant) [58,59,60,61,62,63,64].