ADPKD is a monogenic disease caused mainly by mutations in PKD1 gene (accounts approximately for 85% of cases) which encodes polycystin-1 (PC1) and PKD2 gene (accounts approximately for 15% of cases) which encodes polcystin-2 (PC2) [12,13]. This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.