HNF1B and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: In this sense, Aneta Przepiorski and coworkers in 2018 knocked out the HNF1β transcription factor gene in renal organoids by CRISPR-Cas9, which is known to be one of the genes responsible for ADTKD and plays an essential role in tubulogenesis [139].