PGP and colorectal neoplasm: However, the endosomal vs. lysosomal localization of Pgp may be affected by the cell type and the physiological state of the cell as indicated by the findings of Katayama et al. [56], who reported a primary subcellular localization of Pgp in the lysosomal degradation pathway of a human colorectal tumor cell line (HCT-15).