Besides EZH2 overexpression, various point mutations in EZH2 have also been reported to result in high levels of H3K27me3 signals, including mutations at tyrosine 641 (Y641) [106,107], alanine 677, and alanine 687 (A677 and A687) [108,109], thereby inhibiting tumor suppressor genes to favor cancer progression. This evidence concerns the gene EZH2 and cancer.