SCD and cancer: Moreover, Yi et al. indicated that PI3K/Akt signaling inhibits ferroptosis in cancer cells via a pathway consisting of mTOR complex 1 (mTORC1), sterol regulatory element-binding proteins 1 (SREBP1) and stearoyl-coenzyme A desaturase 1 (SCD1), where SCD1 finally leads to the production of monounsaturated fatty acids [107].