AKT1 and myocardial infarction: Moreover, it can be restored by antioxidant treatment with N-acetyl cysteine (NAC), by improving Akt and STAT3 activation, and by facilitating the cross talk between the PI3K/Akt and JAK2/STAT3 signaling pathways, resulting in attenuated myocardial IRI and post-MI LV dysfunction.