The frequency of somatic ADGRE5 mutations, verified in large cohorts, such as The Cancer Genome Atlas (TCGA), the Cancer Genome Project (CGP), and the International Cancer Genome Consortium (ICGC), and, thus, their impact on cancer is very low (cBioPortal for Cancer Genomics, cbioportal.org; accessed on 28 March 2022) (Figure 2b). The gene discussed is ADGRE5; the disease is cancer.