ADGRE5 and thyroid gland undifferentiated (anaplastic) carcinoma: Immunohistological findings in humans support the experimental data: CD97 is especially induced in pervasive invasive tumors, such as GBM and anaplastic thyroid carcinoma [70,73], and is increased in tumor cell buds at the invasion front or in cells at the tumor margin of several different carcinomas [32,67,72].