YY2 and central nervous system cancer: In cancer cells, overexpressed LINC00665 can reduce the stability of transcriptional regulators MTF1 and YY2, and downregulate the expression of microtubule localization protein 1 (GTSE1) in G2 and S phases, thereby attenuating the proliferation, migration, and invasion of glioma cells and apoptosis inhibition [43].