In lung adenocarcinoma, LINC00665 can directly bind to YB-1 protein to enhance its stability, and the accumulated nuclear YB-1 activates the expression of ANGPT4, ANGPTL3, and VEGFA by binding to the promoter, facilitating tumor-associated angiogenesis in vitro and in vivo [32]. The gene discussed is YBX1; the disease is lung adenocarcinoma.