In colorectal cancer, LINC00665 can interact with U2AF2, enhance the binding between U2AF2 and CTNNB1 mRNA, and increase the stability of CTNNB1 mRNA, thereby further activating the Wnt/β-catenin signaling pathway and stimulating the proliferation and invasion of colorectal cancer cells. This evidence concerns the gene CTNNB1 and colorectal cancer.