A study in gastric cancer found that silencing of LINC00665 can downregulate the expression levels of TGF-β and its downstream factors Smad-2 and α-SMA, indicating that LINC00665 may promote the progression of EMT in gastric cancer through the TGF-β/Smad-2 signaling pathway [24]. Here, SMAD2 is linked to gastric cancer.