To characterize the function of LINC00152 in human HCC cells, we generated LINC00152 knockout cell lines (ΔLINC00152) using the DECKO system, a paired single guide RNAs CRISPR/Cas9 technology, specifically designed for the genomic perturbation of lnc-RNAs [19,20]. Here, CYTOR is linked to hepatocellular carcinoma.