In the 3-nitropropionic acid (3-NP) HD rat model, inhibition of RhoA/ROCK signaling using Fasudil or simvastatin inhibited 3-NP-induced neurotoxicity and, interestingly, also mitochondrial dysfunction through a mechanism involving the ROCK/p-Akt/eNOS pathway [206]. This evidence concerns the gene RHOA and Huntington disease.