Taken together, melanoma cells secreted a variety of proinflammatory factors, mainly cytokines, such as IL-1β and IL-8, and chemokines, such as CXCL10, CXCL11, and CCL20, during CIS, while during TIS, melanoma cells produced lower levels of SASP proteins. This evidence concerns the gene CXCL10 and in situ carcinoma.