NLRP3 and Sepsis: In septic rats, an antagonist of the adenosine diphosphate (ADP) receptor P2Y12, clopidogrel, has been shown to reduce the activity of the platelet NLRP3 inflammasome, as well as the circulating concentration of IL1β and IL18 and sepsis-induced kidney injury, supporting an immune role of platelets in sepsis through their NLRP3 inflammasome [110].