To gain more insight into the involvement of NF-KB activation in colon carcinoma angiogenesis, TNFα (10 pg/mL), a promotor of NF-kB, was used to treat HT-29 and Caco-2 colon carcinoma cells in the presence and absence of crocin (40 μg/mL) for 24 h. The gene discussed is TNF; the disease is colon carcinoma.