In the context of infection, influenza A virus (IAV) induces activation of pyroptotic, apoptotic, and necroptotic proteins, and loss of RIPK3 protects against much of the cell death, but combined deletion of caspase-8 and RIPK3 is necessary to further reduce cell death [9], providing additional mechanistic evidence of overlaps in the functions of molecules involved in cell death activation. The gene discussed is CASP8; the disease is infection.