Inhibition of excessively activated HDACs I/IIa in the degenerating retina of rd1 RP model mice, which have a loss-of-function mutation in the gene encoding for the β-subunit of rod photoreceptor cGMP phosphodiesterase-6, was reported to suppress photoreceptor death [61]; whether the effect involved PGC-1α upregulation would be an interesting point as a future study. Here, PPARGC1A is linked to retinitis pigmentosa 1.