NLRP3 and metabolic dysfunction-associated steatohepatitis: Moreover, Mridha et al. used a NLRP3 inhibitor, MCC950, in order to reduce liver injury in NASH in a murine model of steatohepatitis caused by feeding mice with MCD/WD (Western diet), leading to a decrease in transaminase levels, liver fibrosis, and cytokine levels compared to the mice treated with the vehicle [104].