CRK and Alzheimer disease: Alzheimer’s disease neuropathology is associated with hyperactivation of the PI3K/Akt/mTor pathway, decreased activity of AMPK, increased activity of p38 MAPK, and inhibition of the Wnt pathway [246]; whereas Parkinson’s disease neuropathology has been found to involve alterations in the autophagic/lysosomal pathway that include disruption of Rab7 function and intracellular trafficking and involvement of the p38/JNK pathway [247,248].