ANXA1 and colitis: On the other hand, Annexin A1-deficient animals have increased susceptibility to DSS-induced colitis in association with greater morbidity and mucosal injury that is ameliorated by an agonist for Annexin A1 receptors, thereby suggestive of protective and reparative properties of endogenous Annexin A1 on the intestinal mucosal epithelium [33].