Given the well-documented anti-inflammatory effects of GILZ, we conjecture that reduction of GILZ in OC may be helpful (i.e., favoring pro-inflammatory activity) and compensatory for the presence of Candida albicans (i.e., to reduce fungal colonization and activity) while a similar reduction of GILZ in the microenvironment in OLP could exacerbate the underlying pathology. Here, TSC22D3 is linked to oral lichen planus.