Intriguingly, BAP1 loss can be frequently detected in CCA, and several reports indicate that the chemical inhibition of histone deacetylases (HDAC), which are also involved in DNA repair process, reverses the phenotypic effects of BAP1 inactivation, promoting accumulation of damaged DNA and inducing cancer cell death [186,187,188]. The gene discussed is HDAC9; the disease is cholangiocarcinoma.