CHEK1 and cholangiocarcinoma: As far as we know, NCT02124148 is the sole clinical application involving metastatic CCA patients elucidating the efficacy of combining the dual CHK1/2 kinase inhibitor Prexasertib (LY2606368) with standard chemotherapeutics, including cisplatin, showing promising phase I indications about patient response and drug tolerability [160].