YTHDC1 and cancer: As for SRSF3, it has been reported that SRSF3 has great influence on various type of cancers via splicing regulation [26,27,28,29] In addition, dephosphorylated SRSF3 selectively mediates export of methylated mRNAs to the cytoplasm through YTHDC1 binding by association with NXF1 [23].