Thus, the increased mRNA levels of insulin receptor (Insr) (Figure 5) observed in both renin-b-overexpressing H9c2 cells have the potential to initiate the activation of the PI3K/AKT/mTOR signaling cascade, resulting in AKT-mediated cardioprotective effects during ischemia-related conditions. The gene discussed is AKT1; the disease is ischemia.