TLR3 and periodontal disorder: By significantly increasing TLR3 expression with TQ modulation in G-MSCs, an elevated TLR3 priming by DAMPS [46] is facilitated to detect primary signals of periodontal disease [46] and to promote a cell cycle transition of G-MSCs into stages of differentiation and maturation, shifting the cells into a highly osteogenic phenotype [1,48] that is pivotal for regenerative periodontal therapy [49].