CD274 and renal carcinoma: In this study, we analyzed the global gene expression profile of B7 family members, including PD-L1, PD-L2, B7-H2, B7-H3, B7-H4, B7-H5, B7-H6, and B7-H7 in renal cancer cells upon treatment with different targeted therapies, and we tested by functional in vitro experiments the effect of B7 expression on the sensitivity to targeted therapies in renal cancer cells.