In sum, the aim of the current study was to characterize NCI-H295R, MUC-1 and TVBF-7 regarding their underlying heterogenic geno- and phenotypes, to thereby reveal varying steroidogenic and down-stream signalling/secretion capacities and highlight their significant, but not interchangeable values for new therapeutic and mechanistic studies by representing various clusters known for ACC patients. This evidence concerns the gene MUC1 and adrenal cortex carcinoma.