Interestingly, caspase-8−/−/RIPK3−/− or caspase-8−/−/MLKL−/− double-ko mice develop hyperinflammation and lymphadenopathy, a phenotype resembling that observed in CD95-deficiency Lpr mice strongly suggesting that these factors control an additional mechanism in which CD95 could be involved too. Here, FAS is linked to Lymphadenopathy.