PNPLA2 and metabolic syndrome: While the concomitant increases in lipolytic enzymes, i.e., ATGL and β-HAD, in the Obese(-) group appear to prevent augmented deposition of lipid fractions compared with the subLean group, the development of metabolic syndrome reduced these compensatory cellular mechanisms and led to lipid accumulation (FFA, DAG and TAG) within the adipocytes.