In particular, they show that in LNCap prostate cancer cells, DJ-1, by inhibiting JNK and Bcl2 phosphorylation as well as Beclin1 and Bcl2 dissociation, causes a reduction of microtubule-associated proteins 1A/1B light chain 3B, namely LC3 (MAP1LC3B) and of auto-phagosome formation. This evidence concerns the gene BCL2 and Familial prostate cancer.