Some studies report that there is no evidence that a history of asymptomatic or mild SARS-CoV-2 infection may negatively affect female fertility or ART outcomes, as well as the possibility of vertical transmission of SARS-CoV-2, in women with mild symptoms or those without symptoms of COVID–19 [31,32,33], except that the presence of S-protein on cumulus cells has be highlighted [34,35]. Here, PROS1 is linked to COVID-19.