To explore the possible mechanisms through which Rabeprazole acts in vivo, we next assessed the levels of factors that are involved in the reparative HIF-1α/FoxM1 signaling pathway, which we previously found to be responsible for vascular repair and the resolution of inflammation in mouse models of endotoxemic and polymicrobial sepsis-induced lung injury [6]. This evidence concerns the gene FOXM1 and Sepsis.