Gong et al. showed that HIF-2α plays an important role in inhibiting adherens junctional disruption in acute lung injury by inducing VE-PTP expression, which reduces VE-Cadherin endocytosis by enhancing VE-cadherin dephosphorylation, and thus augments endothelial adherens junction integrity and endothelial barrier function [61]. This evidence concerns the gene EPAS1 and injury.