As expected, the serum cholesterol level of these mice infected with AAV-PCSK9 and fed with a high-cholesterol diet was substantially higher than that of control mice without AAV-PCSK9 infection and fed with normal diet (652 ± 114 (n = 8) mg/dl for the former group vs. 122 ± 5 (n = 5) mg/dl for the latter group, p < 0.001). The gene discussed is PCSK9; the disease is infection.