Adipocyte-specific depletion of miR-34a reprograms ATMs from pro-inflammatory M1-like to anti-inflammatory M2-like phenotype and protects mice from obesity-associated inflammation, glucose intolerance, insulin resistance through repressing Krüppel-like factor 4 (KLF4) expression [75]. This evidence concerns the gene KLF4 and obesity due to melanocortin 4 receptor deficiency.