NLRP3 and obesity due to melanocortin 4 receptor deficiency: The production of inflammatory cytokines during obesity has been well demonstrated to be regulated by the signaling pathway of inhibitor of κB kinase-β (IKK-β) and nuclear factor-κB (NF-κB) [46,47], c-Jun N-terminal kinase (JNK) [48,49], and the NLR family pyrin domain containing 3 (NLRP3) inflammasome [50,51,52].