For example, the activated form of NF-κB regulates the expression of many genes (including TNFα, IL-1, IL-6, VCAM1, CCL20, MMP9, MMP3 and RGS17) that are expressed in medial smooth muscle cells of early atherosclerotic lesions [13], in experimental models of atherosclerosis [14] and after vascular injury [15]. The gene discussed is NFKB1; the disease is atherosclerosis.