LIF activation of NOTCH1 signaling by H3K27me3 demethylation through the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) histone demethylase correlated with “stemness” related genes, sphere formation, self-renewal and metastasis in osteosarcoma [75]. The gene discussed is KDM6A; the disease is osteosarcoma.