A meta-analysis of clinical trials consisting of three HDAC inhibitors (vorinostat, panobinostat and ricolinostat) concluded that panobinostat is the most effective of these three HDAC inhibitors, with an ORR (Overall Response Rate) of 0.64 in patients with relapsed/refractory multiple myeloma [142]. The gene discussed is HDAC9; the disease is AL amyloidosis.