NOTCH1 and primary cutaneous T-cell non-Hodgkin lymphoma: In cutaneous T cell lymphoma (CTCL), the binding of the epigenetic reader bromodomain-containing protein 4 (BRD4) to promoter and enhancer regions of CD4+ T cells of CTCL patients resulted in tumorigenesis through increased expression of NOTCH1 and RBPJ genes [76].