DICER, an enzyme involved in processing of microRNAs that are regulating the EMT pathway, showed a decrease in expression in breast cancer cell lines after hypoxic exposure, even though KDM6A and KDM6B were enriched in the promoter region, highlighting the importance of oxygen to carry out demethylating activity of KDM6A and KDM6B [37]. The gene discussed is KDM6A; the disease is breast carcinoma.