Signaling pathways governed by the nucleotide-binding and oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, and signal transducer and activator of transcription-3 (STAT-3) are implicated in different chronic inflammatory diseases along with induction of cytokine release in COVID-19 [5,9,10,11,12,13,14]. The gene discussed is STAT3; the disease is COVID-19.