Namely, we have recently considered it rational to investigate the biological effect of three genes on bladder cancer, i.e., WW Domain Containing Oxidoreductase (WWOX), Transcription Factor AP-2 Alpha (TFAP2A) and Transcription Factor AP-2 Gamma (TFAP2C), the last two encoding Activating Enhancer-Binding Protein 2 Alpha (AP-2α) and AP-2γ, respectively. This evidence concerns the gene WWOX and urinary bladder cancer.