For instance, the combination of circ-CDYL with HIF1AN and HDGF has been shown to be an effective biomarker for HCC, with odds ratios of 1.09 (95% confidence interval (CI), 1.02−1.17) and 124.58 (95% CI, 13.26−1170.56), respectively [46]. This evidence concerns the gene HDGF and hepatocellular carcinoma.