It was shown that in a model of viral infection, miR-155 expression is induced in a TLR/MyD88-independent but retinoic acid-inducible gene I/JNK/NF-κB-dependent pathway, which leads to downregulation of suppressor of cytokine signaling 1 (SOCS1), and thus enhancement of type I IFN signaling, which may exacerbate inflammation [210]. Here, SOCS1 is linked to viral infectious disease.