TRERF1 and experimental autoimmune encephalomyelitis: On the other hand, 3MA-ASCs and Rapa-ASCs both upregulate PGE2 secretion when activated with hIFNγ, indicating that autophagy inhibition with 3-MA may also have therapeutic benefit in certain disease contexts, as was proposed by Dang and colleagues in the experimental autoimmune encephalomyelitis (EAE) mouse model [19].