Another study conducted by Kim and collaborators showed that Rapa preconditioning of hASCs increased both mRNA and protein expression of the immunosuppressive cytokines IDO, IL-10, and TGF-β, suppressed T helper 17 (Th17) cells thereby promoting T regulatory cells (Tregs), and prolonged survival in a mouse model of graft-versus-host-disease (GVHD) [29]. This evidence concerns the gene IL10 and graft versus host disease.