Using rat pancreatic adenocarcinoma CD151/TSPAN8 knockdown exosomes had little or no effect on stroma cell activation—upregulation of cytokines, cytokine receptors, and proteases—and the promotion of inflammatory cytokine expression in hematopoietic cells, all of which are at least partly due to reduced binding/uptake of CD151-deficient and/or Tspan8-deficient exosomes [88]. Here, TSPAN8 is linked to pancreatic adenocarcinoma.