CD274 and hereditary clear cell renal cell carcinoma: In contrast to other cancers, for example, melanoma and renal cell carcinoma, where inhibition of the PD-1-PDL1 pathway using checkpoint inhibitors has improved clinical outcomes by reinvigorating antitumour T cell responses [21,22], TRM expressing PD-1 have been shown to maintain cytotoxicity in the tumour microenvironment (TME) [15,16,23,24].