NR4A1 and cancer: For example, 1,1-bis(3′-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) was identified as an NR4A1 antagonist, and DIM-C-pPhOH and several 3,5-disubstituted phenyl analogs inhibit cell proliferation and migration/invasion by modulating the expression of NR4A1-regulated genes in pancreatic and other cancer cell lines [4].