NR4A1 and pancreatic neoplasm: Furthermore, as shown in Supplemental Figure S6, TTD (≥10 μM) significantly inhibited NBRE reporter gene activity and cell proliferation (IC50 value = 15.89 μM) in a dose-dependent manner in MiaPaCa-2 cells, another human pancreatic cancer cell line known to overexpress NR4A1 [11].