The inhibitory effect of FCN and its structural analogs, berbamine (BBM), isotetrandrine (ITTD), TTD, and tubocurarine (TCR) on NR4A1-dependent transactivation was determined in Panc-1 human pancreatic cancer cells transfected with a luciferase reporter gene containing NR4A1-binding response elements (NBRE-Luc) (Figure 1A,B). This evidence concerns the gene NR4A1 and familial pancreatic carcinoma.