PIEZO1 and osteoporosis: According to KEGG pathway analysis based on overlapping DEGs, apart from cardiac muscle and cardiovascular diseases, general biological function, and malaria, pathways enriched in mineral absorption were shown to play key roles in several bone-related diseases, such as bone loss [53] and osteoporosis [54], suggesting that when it comes to osteoporosis research, it is meaningful to consider mineral absorption by targeting Piezo1.